Amaranthus spinosus Attenuated Obesity-Induced Metabolic Disorders in High-Carbohydrate-High-Fat Diet-Fed Obese Rats.
Category:- Journal; Year:- 2021
Discipline:- Pharmacy Discipline
School:- Life Science School
Abstract
Amaranthus spinosus is a common vegetable of Bangladesh and
well-known for its ethnomedicinal uses. In this study, we have evaluated the
ability of powdered supplementation, methanol extract, and aqueous extract of
A. spinosus in attenuating in high-carbohydrate-high-fat (HCHF) diet-induced
obesity and associated metabolic disorders in female obese rates. Several
parameters have been analyzed in this study including body weight, organ
weight, fat deposition, glycemic status, lipid levels, hepatic and renal
biomarkers, hepatic antioxidant status, and hepatosteatosis. All three samples
of A. spinosus significantly reduced weight gain, organ weight, and abdominal
fat deposition. Improved glucose tolerance and lipid parameters were seen in
obese rats administered with A. spinosus powder, methanol extract, and aqueous
extract. Serum alanine aminotransferase (ALT), aspartate aminotransferase
(AST), alkaline phosphatase (ALP), and creatine kinase levels were normalized
by the test samples. A. spinosus boosted hepatic antioxidant levels including
reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and
glutathione peroxidase (GPx). Histopathology of liver tissue revealed increased
fat infiltration and higher steatosis score in HCHF diet-fed obese rats which
was brought down by A. spinosus. Analyzing all the results it can be concluded
that this medicinal herb is beneficial in the management of obesity and
obesity-induced metabolic disorders, making it a prospective food supplement.