Design and quantitative analysis of low loss and extremely sensitive PCF-based biosensor for cancerous cell detection

Abstract

This paper has modelled and quantitatively analyzed a hollow-core PCF to evaluate its performance as a biosensor. This biosensor is specifically designed to sense four types of cancerous cells, namely Jurkat, HeLa, MCF-7, and Basal, representing the names of blood, cervical, breast, and skin cells. The designed PCF has maintained a minimum of 0.2827 numerical aperture at 1.3 µm wavelength for the four types of cells. The effective absorption and confinement loss values have been exceptionally low for this PCF. The maximum values of these two parameters are only 2.43 × 10–7 cm−1 and 1.91 × 10–8 dB/m correspondingly at 1.3 µm. At the same wavelength, this biosensor has offered a higher value of relative sensitivity for the four types of cells that vary from 88.12% to 89.65%. In addition to these traditional values of performance indices, the simple PCF structure offers a broad likelihood of implementation using the persisting fabrication process.