Dr. Jamil Ahmad Shilpi
Professor



After completion of my B Pharm (Hons) and M Pharm (thesis) from University of Dhaka in 2001, I joined Khulna University in 2002 as a lecturer at Pharmacy Discipline. Later I completed my PhD from University of Strathclyde in 2009. My PhD project was focused on the antibacterial activity of natural products from Bangladeshi medicinal plants. Later I worked as a Bright Sparks Postdoctoral Researcher at the Centre for Natural Products  and Drug Discovery,  University Malaya from 2013 to 2015.

My current research focuses on evidence based bioactivity study of native medicinal plants, plants of the Sundarbans and bioactivity directed chromatographic separation of natural products.

My teaching areas are natural products of therapeutic value, pharmaceutical analysis, drug discovery from natural sources.

Web of Science ResearcherID: AAI-9213-2020; h-index: 25

ORCID author ID: http://orcid.org/0000-0001-8938-9240; Scopus h-index: 27;

Google scholar h-index: 37

AD Scientific Index: https://www.adscientificindex.com/scientist.php?id=554760

PhD (Natural products)

2005- 2009: University of Strathclyde, Glasgow, UK

M. Pharm (Thesis)

2000-2001: University of Dhaka, Dhaka, Bangladesh

B. Pharm (Hons.)

1995-1999: University of Dhaka, Bangladesh

Current projects are focused on medicinal plants used in ethnomedicinal practice in Bangladesh; mangrove plants, fungal endophytes, soil bacteria from the Sundarbans mangrove forest. Samples selected upon intensive study of their ethnobotanical uses are investigated by established in-vitro and in-vivo models to justify their traditional use. Promising plants are then subjected to chromatographic and spectroscopic analyses to identify the active principle(s). 

Evidence based in silico bioactivity screening of natural products.

PI

Creation of a library of compounds produced by mangrove plants of the Sundarbans to serve as a source of reference for researchers and in silico screening of the library for anticancer drug discovery. Funded by Ministry of Education (2022-2025, BDT 1628000/-)

PI

GC-MS Analysis of Essential Oils with their Antibiofilm, Efflux Pump Inhibitory Activity Investigation by In vitro and In silico Methods. Funded by Khulna University (2022-2024, BDT 450000/-)


Vice president

PSE-NPS 2020 Summit, 16-18 January 2020, Khulna University, jointly organized by Phytochemical society of Europe and Pharmacy Discipline, Khulna University.


DSPM and member

Higher Education Quality Enhancement Project (HEQEP) of UGC, Bangladesh funded by World Bank, (2017-2018); approx. value USD 200000, Title: Development of blended teaching and learning facility to produce quality pharmacy graduates for meeting 21st century challenges


Principal Investigator

Ministry of Education, Bangladesh funded project (2016-2019); TitleExploring fungal endophytes from the Sundarbans mangrove forest as a potential source of anticancer and antimicrobial drug discovery


Postdoctoral Research Fellow 

Apr’ 2013-Mar’ 2015, Centre for Natural Products and Drug Discovery (CENAR), University of Malaya, 50603 Kuala Lumpur, Malaysia


Graduate Teaching Assistant

Oct’ 2005-Sept’ 2009, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK

No Data Available

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·        Akhter T, Bristy NY, Dutta AK, Sarker DP, Ahmed KS, Hossain H, Shilpi JA, Uddin SJ. Chemical and pharmacological potential of Adiantum philippense Linn and further molecular simulation study of its compounds against COX-2: An unexplored medicinal fern. Tropical Journal of Natural Product Research. 2023, 7(9):3842-3855. http://www.doi.org/10.26538/tjnpr/v7i9.1

·       SMN Zihad, Sifat N, Islam MA, Monjur-Al-Hossain ASM. Sikdar KMYK, Sarker MMR, Shilpi JA, Uddin SJ. Role of pattern recognition receptor in sensing Mycobacterium tuberculosis. Heliyon; 9(10): e20636. 10.1016/j.heliyon.2023.e20636

       Ema RS, Zihad SMN, Islam MN, SIfat N, Rouf R, Shilpi JA, Uddin SJ. Analgesic, anti-inflammatory activity and metabolite profiling of the methanolic extract of Callicarpa arborea Roxb. leaves. Journal of Ethnopharmacology. 2023, 300; 115757. https://doi.org/10.1016/j.jep.2022.115757


Hematpoor A, Liew SY, Omar H, Shilpi JA, Zahari A, Syamsir DR, Salleh HM, Tohar N, Kim RPT, Qureshi AK, Nasrullah AA, Chan G, Tiong SH, Hamdi OAA, Othman MR, Leong ST, Awang K, Mawi M, Asib M. Toxicity of Malaysian Medicinal Plant Extracts Against Sitophilus oryzae and Rhyzopertha dominica. Pertanika Journal of Tropical Agricultural Science. 2022; 45(4): 1137-1160. https://doi.org/10.47836/pjtas.45.4.17


Zihad SMNK, Hasan MT, Sultana MS, Nath S, Nahar L, Rashid MA, Uddin SJ, Sarker SD, Shilpi JA. Isolation and characterization of antibacterial compounds from Aspergillus fumigates: An endophytic fungus from mangrove plant of the Sundarbans. Evidence-Based Complementary and Alternative Medicine. 2022; Article ID 9600079. https://doi.org/10.1155/2022/9600079

·        Islam MT. Quispe C, Herrera-Bravo J, Rahman MM, Hossain R, Sarker C, Raihan MA, Chowdhury MM, Uddin SJ, Shilpi JA, Sousa JMC, Melo-Cavalcante AAC, Mubarak MS, Sharifi-Rad J, Calina D. Activities and molecular mechanisms of diterpenes, diterpenoids, and their derivatives in rheumatoid arthritis. Evidence-Based Complementary and Alternative Medicine. 2022: Article ID 4787643. https://doi.org/10.1155/2022/4787643

·      Khatun A, Rahman M, Nesa ML, Looi CY, Wong WF, Hazni H, Mahdzir MA, Uddin SJ, Awang K, Shilpi JA. Analgesic, anti-inflammatory and NF-κB inhibitory activity of aerial parts of Cestrum diurnum. Clinical Phytoscience. 2022; 8:11. https://doi.org/10.1186/s40816-022-00340-5

·     Hasan MM, Zilani MNH, Akter S, Nasrin P, Shajib GMA, Islam MA, Biswas P, Mahmud S, Saleh MA, Hasan MN, Uddin SJ, Shilpi JA. UHPLC-Q/Orbitrap/MS based chemical fingerprinting and hepatoprotective potential of medicinal plant Morinda angustifolia Roxb. South African Journal of Botany. 2022; 148: 561-572. https://doi.org/10.1016/j.sajb.2022.05.037

·       Karmakar UK, Shilpi JA, Hossain MH, Kundu P. Phytochemical screening and antioxidant potential of Portulaca oleracea Linn. Khulna University Studies. 2021; 18: 27-39

·      Zilani MNH, Islam MA, Biswas P, Anisuzzman M, Hossain, Shilpi JA, Hasan MN, Hossain MG. Metabolite profiling, anti-inflammatory, analgesic potentials of edible herb Colocasia gigantea and molecular docking study against COX-II enzyme. Journal of Ethnopharmacology. 2021; 281: 114577. https://doi.org/10.1016/j.jep.2021.114577

·    Prince MRU, Zihad SMNK, Ghosh P, Sifat N, Rouf R, Shajib GMA, Alam MA, Shilpi JA, Uddin SJ. Amaranthus spinosus attenuated obesity-induced metabolic disorders in high-carbohydrate-high-fat diet-fed obese rats.  Frontiers in Nutrition. 2021, 8:653918. 10.3389/fnut.2021.653918

·     Zihad SMK, Uddin SJ, Sifat N, Lovely F, Rouf R, Shilpi JA, Sheikh BYS, Göransson U. Antioxidant properties and phenolic profiling by UPLC-QTOF-MS of Ajwah, Safawy and Sukkari cultivars of date palm. Biochemistry and Biophysics Reports. 2021, 25: 100909. https://doi.org/10.1016/j.bbrep.2021.100909

·       Uddin SJ, Hasan MF, Afroz M, Sarker DK, Rouf R, Islam MT, Shilpi JA, Mubarak MS. Curcumin and its multi-target function against pain and inflammation: An update of pre-clinical data. Curret Drug Targets. 2021, 22(6): 656 – 671. 10.2174/1389450121666200925150022

·      Siraj A, Howlader SI, Rahman S, Shilpi JA, Seidel V. Antinociceptive and sedative activity of Vernonia patula and predictive interactions of its phenolic compounds with the cannabinoid type 1 receptor. Phytotherapy Research. 2021; 35:1069–1079. https://doi.org/10.1002/ptr.6876

·    Ali ES, Sharker SM, Islam MT, Khan IN, Shaw S, Rahman MA, Uddin SJ, Shill MC, Rehman S, Das N, Ahmad S, Shilpi JA, Tripathi S, Mishra SK, Mubarak MS. Targeting cancer cells with nanotherapeutics and nanodiagnostics: Current status and future perspectives. Seminars in Cancer Biology. 2021; 69:52-68. 10.1016/j.semcancer.2020.01.011


Book chapter: Shilpi JA and Uddin SJ. Analgesic and antipyretic natural products. In: Annual Reports in Medicinal Chemistry, Medicinal Natural Products: A Disease-Focused Approach. Eds: Sarker SD and Nahar L. Academic Press. 2020; Vol. 55: pp. 435-458. https://doi.org/10.1016/bs.armc.2020.03.003


Sifat N, Zihad SMNK, Lovely F, Rouf R, Shajib, Alam MA, Shilpi JA, Uddin SJ. Supplementation of Heliotropium indicum Linn attenuates obesity and associated metabolic disorders in high-carbohydrate-high-fat diet-induced obese rats. Journal of Food Biochemistry. 2020, 44(11), e13444. https://doi.org/10.1111/jfbc.13444


Islam MT, Ali ES, Khan IN, Shaw S, Uddin SJ, Rouf R, Dev S, Saravi SSS, Das N, Tripathi S, Yele SU, Das AK, Shilpi JA, Mishra SK, Mubarak MS. Anticancer perspectives on the fungal-derived polyphenolic hispolon. Anticancer Agents in Medicinal Chemistry. 2020; 20: 1636-1647. 10.2174/1871520620666200619164947


Islam MT, Sarkar C, El-Kersh DM, Jamaddar S, Uddin SJ, Shilpi JA, Mubarak MS. Natural products and their derivatives against coronavirus: A review of the non-clinical and pre-clinical data. Phytotherapy Research. 2020; 1-22. 10.1002/ptr.6700


Afroz M, Akter S, Ahmed A, Rouf R, Shilpi JA, Trialongo E, Sarker SD, Goransson U, Uddin SJ. Ethnobotany and antimicrobial peptides from plants of the Solanaceae family: an update and future prospects. Frontiers in Pharmacology. 2020; 11:565. 10.3389/fphar.2020.00565 


Uddin SJ, Afroz M, Zihad SMNK, Rhaman MS, Akter S, Khan IN, Al-Rabbi SMS, Rouf R, Islam MT, Shilpi JA. A Systematic Review on anti-diabetic and cardioprotective potential of gallic acid: A widespread dietary phytoconstituent. Food Reviews International. 2020; in press 10.1080/87559129.2020.1734609


Afroz M, Zihad SMNK, Uddin SJ, Rouf R, Rahman MS, Islam MT, Khan IN, Ali ES, Aziz S, Shilpi JA, Nahar L, Sarker SD. A systematic review on antioxidant and anti-inflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking. Phytotherapy Research. 2019; 33: 2585-2608. 10.1002/ptr.6428


Andrade AWL, Figueiredo DDR, Islam MT, Nunes AMV, Machado KC, Machado KC, Uddin SJ, Shilpi JA, Rouf R, Melo-Cavalcante AAC, David JM, Mubarakh MS, Costa JP. Toxicological evaluation of the biflavonoid, agathisflavone in albino Swiss Mice. Biomedicine & Pharmacotherapy. 2019; 110: 68-73. 10.1016/j.biopha.2018.11.050


Islam MT, Khalipha ABR, Bagchi R, Mondal M, Smrity SZ, Uddin SJ, Shilpi JA, Rouf R. Anticancer activity of thymol: A literature-based review and docking study emphasized on its anticancer mechanisms. IUBMB Life. 2019; 71: 9-19. https://doi.org/10.1002/iub.1935


MT, Blicharska N, Shilpi JA, Seidel V. Investigation of the anti-TB potential of selected propolis constituents using a molecular docking approach. Scientific Reports. 2018; 8: 12238. https://doi.org/10.1038/s41598-018-30209-y 


Islam MT, et al. Phytol: A review of biomedical activities. Food and Chemical Toxicology. 2018; 121: 82-94. 10.1016/j.fct.2018.08.032


Ali Islam MT, et al. A systematic review on the neuroprotective perspectives of beta-caryophyllene. Phytotherapy Research. 2018; 32: 2376-2388. 10.1002/ptr.6199


Andrade AWL, Machado KC, Machado KC, Figueiredo DDR, David JM, Islam MT, Uddin SJ, Shilpi JA, Costa JP. In vitro antioxidant properties of the biflavonoid agathisflavone. Chemistry Central Journal. 2018; 12:75. 10.1186/s13065-018-0443-0


Gomes Júnior AL, Tchekalarova JD, Machado KDC, Moura AKS, Paz MFCJ, da Mata AMOF, Nogueira TR, Islam MT, Rios MAS, Graças Lopes Citó AMD, Uddin SJ, Shilpi JA, Das AK, Lopes LDS, Melo-Cavalcante AAC. Anxiolytic effect of anacardic acids from cashew (Anacardium occidentale) nut shell in mice. IUBMB Life. 2018;70: 420-431. 10.1002/iub.1738


Braga AL et al. Toxicogenetic study of omeprazole and the modulatory effects of retinol palmitate and ascorbic acid on Allium cepa. Chemosphere. 2018; 204: 220-226. 10.1016/j.chemosphere.2018.04.021


Islam MT, et al. Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer. Cancer Letters. 2018; 420: 129-145. 10.1016/j.canlet.2018.01.074

Zihad SMNK, Saha S, Rony MS, Banu H, Uddin SJ, Shilpi JA, Grice ID. Assessment of the laxative activity of an ethanolic extract of Bambusa arundinacea (Retz.) Willd. shoot. Journal of Ethnopharmacology. 2018; 214: 8-12. 10.1016/j.jep.2017.11.038

Mahdzir MA, Shilpi JA, Mahmud N, Ramasamy S, Awang K. Chemical constituents from Walsura pinnata (Meliaceae). Natural Product Communications. 2017; 12:1397-1400.

Hossain SJ, Islam MR, Pervin T, Iftekharuzzaman M, Hamdi OAA, Mubassara S, Saifuzzaman M, Shilpi JA. Antibacterial, anti-diarrhoeal, analgesic, cytotoxic activities, and GC-MS profiling of Sonneratia apetala (Buch.-Ham.) seed. Preventive Nutrition and Food Science. 2017; 22:157-165.

Zilani MNH, Sultana T, Rahman SMA, Anisuzzaman M, Islam MA, Shilpi JA, Hossain MG. Chemical composition and pharmacological activities of Pisum sativum. BMC Complementary and Alternative Medicine. 2017, 17:171.

Ablat A, Halabi MF, Mohamad J, Hasnan MHH, Hazni H, The SH, Shilpi JA, Mohamed Z, Awang K. Antidiabetic effects of Brucea javanica seeds in type 2 diabetic rats. BMC Complementary and Alternative Medicine. 2017, 17:94.

Sheikh BY, Zihad SMNK, Sifat N, Uddin SJ, Shilpi JA, Hamdi OAA, Hossain H, Rouf R, Jahan IA. Comparative study of neuropharmacological, analgesic properties and phenolic profile of Ajwah, Safawy and Sukkari cultivars of date palm (Phoenix dactylifera). Oriental Pharmacy and Experimental Medicine. 2016; 16: 175–183.

Siraj MA, Shilpi JA, Hossain MG, Uddin SJ, Islam MK, Jahan IA, Hossain H. Anti-inflammatory and antioxidant activity of Acalypha hispida leaf and analysis of its major bioactive polyphenols by HPLC. Advanced Pharmaceutical Bulletin. 2016; 6:275-283.

Zilani MNH, Islam MA, Khushi SS, Shilpi JA, Rahman MM, Hossain MG. Analgesic and antioxidant activities of Colocasia fallax. Oriental Pharmacy and Experimental Medicine. 2016; 16:131–137.

Shilpi JA, Saha S, Lim CS, Nahar L, Sarker SD, Awang K. Advances in chemistry and bioactivity of the genus Chisocheton Blume. Chemistry & Biodiversity. 2016; 13: 483-503.

Rahman M, Khatun A, Uddin SJ, Shilpi JA. Comparative effect of Lannea coromandelica (Houtt.) Merr. leaves and stem barks on acetic acid induced pain model in mice and chromagenic reagents: exploring the analgesic potential and phytochemical groups. Pharmacologyonline. 2016; 148:146-152.

Shilpi JA, Ali MT, Saha S, Hasan S, Gray AI, Seidel V. Molecular docking studies on InhA, MabA and PanK enzymes from Mycobacterium tuberculosis of ellagic acid derivatives from Ludwigia adscendens and Trewia nudiflora. In Silico Pharmacology. 2015; 3:10.

Khan MA, Islam MK, Siraj MA, Saha S, Barman AK, Awang K, Rahman MM, Shilpi JA, Jahan R, Islam E, Rahmatullan M. Ethnomedicinal survey of various communities residing in Garo Hills of Durgapur, Bangladesh. Journal of Ethnobiology and Ethnomedicine. 2015; 11:44.

Hamdi OAA, Anouar EH, Shilpi JA, Trabolsy ZBKA, Zain SBM, Zakaria NSS, Zulkefeli M, Weber JFF, Malek SNA, Rahman SNSA, Awang K. A quantum chemical and statistical study of cytotoxic activity of compounds isolated from Curcuma zedoaria. International Journal of Molecular Sciences. 2015; 16:9450-9468.

Hamdi OAA, Ye LJ, Kamarudin MNA, Hazni H, Paydar M, Looi CY, Shilpi JA, Kadir HA, Awang K. Neuroprotective and antioxidant constituents from Curcuma zedoaria rhizomes. Records of Natural Products. 2015; 9:349-355.

Hamdi OAA, Feroz SR, Shilpi JA, Anouar EH, Mukarram AK, Mohamad SB, Tayyab S, Awang K. Spectrofluorometric and molecular docking studies on the binding of curcumenol and curcumenone to human serum albumin. International Journal of Molecular Sciences. 2015; 16:5180-5193.

Mondal H, Hossain H, Awang K, Saha S, Mamun-Ur-Rashid S, Islam MK, Rahman MS, Jahan IA, Rahman MM, Shilpi JA. Anthelmintic activity of ellagic acid, a major constituent of Alternanthera sessilis against Haemonchus contortus. Pakistan Veterinary Journal. 2015; 35:58-62.

Tahia F, Sikder MAA, Haque MR, Shilpi JA, Awang K, Mansur MAA, Rashid MA. Alkaloids, coumarin and cinnamic acid derivative from Murraya koenigii (Linn.) Spreng. 2015. Dhaka Univ. J. Pharm. Sci. 14: 29-33.

Mondal H, Saha S, Awang K, Hossain H, Ablat A, Islam MK, Jahan IA, Sadhu SK, Hossain MG, Shilpi JA, Uddin SJ. Central-stimulating and analgesic activity of the ethanolic extract of Alternanthera sessilis in mice. BMC Complementary and Alternative Medicine. 2014, 14:398.

Islam MK, Saha S, Biswas NN, Saha S, Hossain H, Jahan IA, Khan TA, Awang K, Shilpi JA. Antinociceptive and Antioxidant Activity of Zanthoxylum budrunga Wall (Rutaceae) Seeds. 2014; Scientific World Journal, vol. 2014, Article ID 869537, 7 pages.

Ablat A, Mohamad J, Awang K, Shilpi JA, Arya A. Evaluation of antidiabetic and antioxidant properties of Brucea javanica seed. 2014; Scientific World Journal, vol. 2014, Article ID 786130, 8 pages.

Islam MK, Saha S, Mahmud I, Mohamad K, Awang K, Uddin SK, Rahman MM, Shilpi JA. An ethnobotanical study of medicinal plants used by tribal and native people of Madhupur forest area, Bangladesh. Journal of Ethnopharmacology. 2014; 151: 921–930.

Saha S, Shilpi JA, Mondal H, Gofur MR, Billah MM, Nahar L, Sarker SD. Bioactivity studies on Musa seminifera Lour. Pharmacognosy Magazine. 2013; 9:315-322.

Saha S, Islam MK, Shilpi JA, Hasan S. Inhibition of VEGF: a novel mechanism to control angiogenesis by Withania somnifera’s key metabolite withaferin A. In Silico Pharmacology. 2013; 1:11.

Saha S, Shilpi JA, Mondal H, Hossain F, Anisuzzaman M, Hasan MM, Cordell GA. Ethnomedicinal, phytochemical and pharmacological profile of the genus Dalbergia L. (Fabaceae). Phytopharmacology. 2013; 4:291-346.

Hossain H, Jahan IA, Howlader SI, Shilpi JA, Dey SK, Hira A, Ahmed A. Anti-inflammatory and antioxidant activities of ethanolic leaf extract of Brownlowia tersa (L.) Kosterm. Oriental Pharmacy and Experimental Medicine. 2013; 13:181-189.

Bokshi B, Zilani MNH, Malakar A, Roy D, Shilpi JA, Sadhu SK. Study of analgesic and antidiarrhoeal activities of Sonneratia caseolaris (linn.) Leaf and stem using different solvent system. Majalah Farmasi Indonesia (Indonesian Journal of Pharmacy). 2013; 24:255-260.

Elmezogi J, Gazala BH, Manal G, Abossa A, Mabrouk E, Abdulmotaleb Z, Shilpi JA. Cytotoxic activity of selected Libyan medicinal plants on human breast adenocarcinoma cell line (MCF-7). Majalah Farmasi Indonesia (Indonesian Journal of Pharmacy). 2013; 24:127-130.

Shilpi JA, Islam ME, Billah MM, Islam KMD, Sabrin F, Uddin SJ, Nahar L, Sarker SD. Antinociceptive, anti-inflammatory and antipyretic activity of mangrove plants: A mini review. Advances in Pharmacological Sciences. 2012; Article ID 576086:1–7.

Pervin R, Sabrin F, Billah MM, Islam KMD, Elmezughhi J, Shilpi JA. Antibacterial and cytotoxic activity of Meyna spinosa Roxb. stem. Turkish Journal of Pharmaceutical Sciences. 2012; 9(2):225–230.

Shilpi JA, Gray AI, Seidel V. New cardenolides from the stem bark of Trewia nudiflora. Fitoterapia. 2010; 81:536–539.

Shilpi JA, Gray AI, Seidel V. Chemical constituents from Ludwigia adscendens Biochemical Systematics and Ecology. 2010; 38:106–109.

Uddin SJ, Rouf R, Shilpi JA, Alamgir M, Nahar L, Sarker SD. Screening of some Bangladeshi medicinal Plants for antibacterial activity. Oriental Pharmacy and Experimental Medicine. 2008; 8:316–321.

Ferdous M, Rouf R, Shilpi JA, Uddin SJ. Antinociceptive activity of the ethanolic extract of Ficus racemosa Lin. (Moraceae) Oriental Pharmacy and Experimental Medicine 2008; 8:93–96.

Uddin SJ, Shilpi JA, Middleton M, Byres M, Shoeb M, Nahar L, Sarker SD. Swarnalin and cis-swarnalin, two new tetrahydrofuran derivatives with free radical scavenging activity, from the aerial parts of Cuscuta reflexa. Natural Product Research. 2007; 21:663–668.

Uddin SJ, Nahar L, Shilpi JA, Shoeb M, Borkowski T, Gibbons S, Middleton M, Byres M, Sarker SD. Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytotherapy Research. 2007; 21:757–761.

Sarker SD, Uddin SJ, Shilpi JA, Rouf R, Ferdous ME, Nahar L. Neuropharmacological properties of Xylocarpus moluccensis. Fitoterapia. 2007; 78:107–111.

Rouf R, Uddin SJ, Shilpi JA, Alamgir M. Assessment of antidiarrhoeal activity of the methanol extract of Xylocarpus granatum bark in mice model. Journal of Ethnopharmacology. 2007; 109:539–542.

Shilpi JA, Rahman MT, Uddin SJ, Alam MS, Sadhu SK, Seidel V. Preliminary pharmacological screening of Bixa orellana L. leaves. Journal of Ethnopharmacology. 2006; 108:264–271.

Uddin SJ, Shilpi JA, Rahman MT, Ferdous M, Rouf R, Sarker SD. Assessment of neuropharmacological activities of Pandanus foetidus (Pandanaceae) in mice. Pharmazie. 2006; 61:362–364.

Uddin SJ, Mondal K, Shilpi JA, Rahman MT. Antidiarrhoeal activity of Cyperus rotundus. Fitoterapia. 2006; 77:134–136.

Rouf R, Uddin SJ, Shilpi JA, Rahman MT, Ferdous MM, Sarker SD. Anti-diarrhoeal properties of Diospyros peregrina in the castor oil-induced diarrhea model in mice. ARS Pharmaceutica. 2006; 47: 81–89.

Rahman MS, Sarder M, Shilpi JA, Hasan CM. Antioxidant and analgesic activity of Clerodendrum viscosum leaf. Oriental Pharmacy and Experimental Medicine. 2006; 6:319323.

Uddin SJ, Shilpi JA, Rouf R, Ferdous MM, Nahar L, Sarker SD. Antinociceptive activity of some Bangladeshi medicinal plant extracts. Oriental Pharmacy and Experimental Medicine. 2006; 6:96–101.

Shilpi JA, Rouf R, Ferdous MM, Uddin SJ. Central nervous system stimulating activity of the ethanolic extract of Fleurya interrupta Guad. (Urticariaceae). Oriental Pharmacy and Experimental Medicine. 2006; 6:21–26.

Alam MA, Haque ME, Shilpi JA, Daulla KA. Antinociceptive Effect of the crude ethanolic extract of Crataeva nurvala. Buch. on mice. Bangladesh Journal of Veterinary Medicine. 2006; 4:65-68.

Uddin SJ, Shilpi JA, Alam SM, Alamgir M, Rahman MT, Sarker SD. Antidiarrhoeal activity of the methanol extract of the barks of Xylocarpus moluccensis in castor oil- and magnesium sulphate-induced diarrhoea models in mice. Journal of Ethnopharmacology. 2005; 101:139–143.

Das AK, Shahid IZ, Choudhuri MSK, Shilpi JA, Ahmed F. Anti-inflammatory, antinociceptive and diuretic activities of Amoora cucullata Roxb. Oriental Pharmacy and Experimental Medicine 2005; 5:37–42.

Rahman MT, Shilpi JA, Ahmed M, Hossain CF. Preliminary pharmacological studies on Piper chaba stem bark. Journal of Ethnopharmacology. 2005; 99:203–209.

Uddin SJ, Shilpi JA, Barua J, Rouf R. Antinociceptive activity of Ceriops decandra leaf and pneumatophore. Fitoterapia. 2005; 76:261–263.

Ahmed F, Selim MS, Shilpi JA. Antibacterial activity of Ludwigia adscendens. Fitoterapia. 2005; 76:473–475.

Shilpi JA, Ray PK, Sarder MM, Uddin SJ. Analgesic activity of Amorphophallus campanulatus tuber. Fitoterapia. 2005; 76:367–369.

Uddin SJ, Ferdous MM, Rouf R, Alam MS, Sarker MAM, Shilpi JA. Evaluation of Antidiarrhoeal activity of Enhydra fluctuans. Journal of Medical Sciences. 2005; 5: 324–327.

Shilpi JA, Rouf R, Sarker MAM, Nahar Q, Ferdous MM, Uddin SJ. Antinociceptive activity of methanol extract of Solanum sisymbrifolium Lamk. Pakistan Journal of Biological Sciences. 2005; 8:1123–1125.

Shilpi JA, Uddin SJ, Hossain M, Sarder MM. Antibacterial and antinociceptive activity study of methanol extract of Mimosa pudica. Khulna University Studies. 2005; 6:35–37.

Shilpi JA, Uddin SJ, Rouf R, Billah MM. Central nervous system depressant activity of Diospyros peregrina bark. Oriental Pharmacy and Experimental Medicine. 2004; 4: 249–252.

Uddin SJ, Shilpi JA, Delazar A, Nahar L, Sarker SD Free radical scavenging activity of some Bangladeshi plant extracts. Oriental Pharmacy and Experimental Medicine. 2004; 4:187–195.

Uddin SJ, Shilpi JA, Murshid GM, Rahman AA, Sarder MM, Alam MA. Determination of the binding sites of arsenic on bovine serum albumin using warfarin (site-I specific probe) and diazepam (site-II specific probe) Journal of Biological Sciences. 2004; 4:609–612.

Alam SMM, Yeasmin L, Reza MN, Shilpi JA, Ahmed F, Akter MJ. Studies on binding parameters of chloramphenicol on bovine serum albumin (BSA) Journal of Biological Sciences. 2004; 4:203–206.

Ahasan MM, Billah MM, Hasan MM, Shilpi JA. Transmission, biochemical manifestation and CD4+ cell count of HIV: A Review. Pakistan Journal of Biological Sciences. 2004; 7:292–300.

Alam SMM, Akter MJ, Reza MN, Ishrat F, Ahmed F, Shilpi JA. Drug-Drug interactions between ciprofloxacin and captopril at binding sites of bovine serum albumin. Pakistan Journal of Biological Sciences. 2004; 7:79–81.

Rahman MT, Ahmed M, Alimuzzaman M, Shilpi JA. Antinociceptive activity of the aerial parts of Solanum xanthocarpum. Fitoterapia. 2003; 74:119–121.

Rahman MT, Alimuzzaman M, Shilpi JA, Hossain MF. Antinociceptive activity of Clausena excavata leaves. Fitoterapia. 2002; 73:701–703.

Ahmed M, Rahman MT, Alimuzzaman M, Shilpi JA. Analgesic sesquiterpene dilactone from Mikania cordata. Fitoterapia. 2001; 72:919–921.

Natural Products Chemistry and Drug Discovery

Naturally occurring Anti-mutagenic and Cytoprotective agents. Fractionation of plants to discover
substances to combat cancer.
6. A strategy for rapid identification of Novel Therapeutic leads from Natural Products.
7. Marine Natural Products as leads to develop new drugs and insecticides. Commercialization of
Plant-derived Natural Products as pharmaceuticals.
8. Naturally Occurring Free Radicals and Anti-oxidants: Hydrogen peroxide in biological system,
protection against oxidants in biological systems, superoxide theory and oxygen toxicity, Lipid
peroxidation- a free radical chain reaction, Free radical and toxicology, free radical as useful
species, Free radical in ageing and diseases like artereosclerosis, ischemic heart diseases, ageing
process and neurodegradative conditions.

Running

Medicinal Chemistry III

Case history of specific drug design

a) Antihypertensive (β-blocker)

b) H2-blocker

c) Semisynthetic penicillin

d) Quinolone derivatives

e) Antidiabetic drugs

f) Cephalosporins

4. Drug design and discovery: Source of drugs, Cost and place of development of drugs, Search of new drugs.


Course learning outcome:

Describe the history of different drug development and identify their sources.

Prepare them for research in new drug development

Running

Pharmaceutical Analysis-IV


4.       Fluorometry and flame photometry

Theoretical considerations, instrumentations, factors influencing intensity of fluorescence, applications in pharmaceutical analysis.

5.       X-ray crystallography

X-rays and diffraction of X-rays by crystals, Bragg’s law, powder diffraction patterns, methods of measurements and analytical applications of X-ray diffraction.

6.       Radiochemical methods of analysis

Fundamentals of radioactivity, natural and induced measurements, principles of Geiger-Muller and scintillation counters, radio-activation and isotope dilution analysis, characterization of radioisotopes, isotope and radioisotope methodology, use of radioisotope in pharmaceutical research.

7.       Polarography: Introduction, theoretical principles, diffusion current and half wave potential, quantitative techniques.


Running
  • Natural Products Chemistry and Drug Discovery
  • Medicinal Chemistry III
  • Pharmaceutical Analysis-IV