A Review on Synthesis of Silver Nanoparticles and its Biological & Synergistic Application

Silver nanoparticles (AgNPs) have been used as antibacterial, antifungal, antiviral, anti-

inflammtory, and antiangiogenic due to its unique properties such as physical, chemical, and

biological properties. The present study on review paper was aimed to investigate antibacterial

activities of silver nanoparticles alone and in combination with conventional antibiotics against

various human pathogenic bacteria. Here, we show that a simple, reliable, cost effective and green

method for the synthesis of AgNPs by treating silver ions with leaf extract. AgNPs was

characterized by ultraviolet-visible absorption spectroscopy, X-ray diffraction (XRD), Fourier

transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), dynamic light

scattering (DLS), and transmission electron microscopy (TEM). Furthermore, the antibacterial

activity of antibiotics or AgNPs, or combinations of AgNPs with an antibiotic was evaluated using

a series of assays: such as- disc diffusion assay (MIC). The result suggested that, in combination

with antibiotics, there were significant antimicrobial effects at lowest concentration of AgNPs

using a novel plant extract. This study presented evidence of antibacterial effects of AgNPs and

their enhanced capacity against various human pathogenic bacteria. These results suggest that

AgNPs could be used as an adjuvant for the treatment of infectious diseases.

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