Voltametric synthesis of catechol derivatives: Characterization and antibacterial activities

The study of reactions between quinones produced from the oxidation of catechol and other nucleophiles due to the mechanistic and synthetic importance of these reactions has a growing interest in recent years. Due to the antioxidant activity and low oxidation potentials of catechol, it can be easily oxidized. On the other hand, catechol derivatives play an important role in mammalian metabolism. Many compounds of this type are known to be secondary metabolites of higher plants. Thus, it was thought that synthesis of compounds with both structures of catechols and indoles would be useful from the point of view of pharmaceutical properties. Catechol derivatives have been used as electron transfer mediators in electrochemical processes due to their high electron transfer efficiency, excellent redox reversibility, and low cost. These compounds as mediators are immobilized on the electrode surface by various methods, such as adsorption mixing into carbon paste electrode, or simply added to the test solution.

In this work, the electrochemical oxidation of catechol in the presence of different nucleophiles at various pHs, concentrations, scan rates will be investigated. The main goal of the investigation is to carry out a qualitative detailed study of the electrochemical oxidation of catechol in aqueous solutions. Electrochemical techniques such as cyclic voltammetry, Differential pulse voltammetry (DPV), Chronoamperometry using the diagnostic criteria for various electrode mechanisms and controlled potential coulometry are used.

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