Samir

Dr. Samir Kumar SADHU

Professor
Address
Pharmacy Discipline, Khulna University, Khulna-9208, Bangladesh
Phone

+88-041-725876

Research Interest

Natural Products Chemistry & Pharmacology

Academic qualification

Doctor of Philosophy (PhD) (03 years): from April 2001 to March 2004, Laboratory of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.  Research field: Natural Products Chemistry

Master of Pharmacy (M. Pharm) (01 year, Research group): from July 1989 to June 1990 (* actual date: from December 1993 to October 1994), Pharmacy Research Laboratory, Department of Pharmacy, University of Dhaka, Dhaka, Bangladesh.  Research field: Phytochemistry and Pharmacology, 1st class 5th position, 63.5% mark

Bachelor of Pharmacy (B. Pharm, Honors) (03 years): from July 1986 to June 1989 (* actual date: from October 1987 to October 1992), Department of Pharmacy, University of Dhaka, Dhaka, Bangladesh.  Subject of study: Pharmacy, 1st class 6th position, 61.8% mark

Higher Secondary Certificate (H. S. C) (02 years): from July 1984 to June 1986, Government P. C. College, Bagerhat, Bangladesh.  Subjects of study: Bangla, English, Mathematics, Biology, Physics, Chemistry. 78.2% mark

Secondary School Certificate (S. S. C) (05 years): from January 1979 to December 1983, Bagerhat M. L. High School, Bagerhat, Bangladesh.  Subjects of study: Bangla, English, Mathematics, Biology, Physics, Chemistry, Geography, History, Sociology, Religion, etc., 74.5% mark

Primary School Education (05 years): from January 1974 to December 1978, P. T. I. Primary School, Bagerhat, Bangladesh.  Subjects of study: Bangla, English, Mathematics, Science, Sociology, Religion, etc.

* This inconsistency is due to political turmoil in Bangladesh

Employment

Professor: from 19 January 2009, Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh

Publication (selected)

  1. K. Karmakar, N. Ishikawa, K. Toume, M. A. Arai, S. K. Sadhu, F. Ahmed, M. Ishibashi, “Sesquiterpenes with TRAIL-resistance overcoming activity from Xanthium strumariumBioorganic and Medicinal Chemistry (in press)
  2. G. Fuentes, K. Toume, M. A. Arai, S. K. Sadhu, F. Ahmed, M. Ishibashi, “Scopadulciol, isolated from Scoparia dulcis, induces β-catenin degradation and overcomes tumor necrosis factor-related apoptosis ligand resistance in AGS human gastric adenocarcinoma cells” Journal Natural Products 78, 864-872, 2015
  3. G. Fuentes, K. Toume, M. A. Arai, S. K. Sadhu, F. Ahmed, M. Ishibashi, “Limonoids with Wnt signal inhibitory activity isolated from the fruits of Azadirachta excelsaPhytochemistry Letters 11, 280-285, 2015
  4. Tahmina, K. Toume, M. A. Arai, S. K. Sadhu, F. Ahmed, M. Ishibashi, “Isolation of alkamides with death receptor-enhancing activities from Piper chabaHeterocycles 90, 1317-1322, 2015
  5. Ohishi, K. Toume, M. A. Arai, S. K. Sadhu, F. Ahmed, T. Mizoguchi, M. Itoh, M. Ishibashi, “Ricinine: A pyridone alkaloid from Ricinus communis that activates the Wnt signaling pathway through casein kinase 1α” Bioorganic and Medicinal chemistry 22, 4597-4601, 2014
  6. -Y.Park, K.Toume, M. A. Arai, S. K. Sadhu, F. Ahmed, M. Ishibashi, “Calotropin: a cardenolide from Calotropis gigantea that inhibits Wnt signaling by increasing casein kinase 1α in colon cancer cells” Chemical and Biological Chemistry 15, 872-878, 2014
  7. A. Arai, K. Uchida, S. K. Sadhu, F. Ahmed, M. Ishibashi, “Physalin H from Solanum nigrum as Hh signaling inhibitor blocks GLI1-DNA complex formation” Beilstein Journal of Organic Chemistry 10, 134-140, 2014
  8. Toume, K. Kamiya, M. A. Arai, N. Mori, S. K. Sadhu, F. Ahmed, M. Ishibashi, “Xylogranin B: a potent Wnt signal inhibitory limonoid from Xylocarpus granatumOrganic Letters 15, 6106-6109, 2013
  9. A. Arai, T. Fujimatsu, K. Uchida, S. K. Sadhu, F. Ahmed, M. Ishibashi, “Hh signaling inhibitors from Vitex negundo, naturally occurring inhibitor of GLI1-DNA complex” Molecular BioSystems 9, 1012-1018, 2013
  10. Minakawa, K. Toume, M. A. Arai, S. K. Sadhu, F. Ahmed, M. Ishibashi, “Eudesmane-type Sesquiterpenoid and Guaianolides from Kandelia candel in a screening program for compounds to overcome TRAIL resistance”  Journal of Natural Products 75, 1431–1435, 2012
  11. Yamaguchi, K. Toume, M. A. Arai, F. Ahmed, S. K. Sadhu, M. Ishibashi, “Phorbol esters with Wnt signal-augmenting effects isolated from Excoecaria indicaNatural Products Communications 7, 475-477, 2012
  12. Koryudzu, M. A. Arai, F. Ahmed, S. K. Sadhu, M. Ishibashi, “A new resin glycoside from Ipomoea maximaNatural Products Communications 7, 219-220, 2012
  13. Rifai, M. A. Arai, S. K. Sadhu, F. Ahmed, M. Ishibashi, “New Hedgehog/GLI signaling inhibitors from Excoecaria agallochaBioorganic and Medicinal Chemistry Letters 21, 718-722, 2011
  14. Ahmed, K. Toume, T. Ohtsuki, M. Rahman, S. K. Sadhu, M. Ishibashi, “Cryptolepine, isolated from Sida acuta, sensitizes human gastric adenocarcinoma cells to TRAIL-induced apoptosis”, Phytotherapy Research 25, 147-150, 2011
  15. Minakawa, K. Toume, F. Ahmed, S. K. Sadhu, T. Ohtsuki, M. A. Arai, M Ishibashi, “Constituents of Pongamia pinnata isolated in a screening for activity to overcome TRAIL-resistance” Chemical and Pharmaceutical Bulletin 58, 1549-1551, 2010
  16. Ahmed, S. K. Sadhu, M. Ishibashi, ”Search for bioactive natural products from medicinal plants of Bangladesh”, Journal of Natural Medicines 64, 393-401, 2010 (Review article)
  17. Ahmed, K. Toume, S. K. Sadhu, T. Ohtsuki, M. A. Arai, M. Ishibashi, “Constituents of Amoora cucullata with TRAIL resistance overcoming activity”, Organic and Biomolecular Chemistry 8, 3696-3703, 2010
  18. S. Abdelfattah, K. Toume, F. Ahmed, S. K. Sadhu, M. Ishibashi, “Cucullamide, a new putrescine bisamide from Amoora cucullata”, Chemical and Pharmaceutical Bulletin 58, 1116-1118, 2010
  19. Ahmed, S. K. Sadhu, T. Ohtsuki, A. Khatun, M. Ishibashi, “Glycosides from Vallaris solanaceae with Trail-resistance-overcoming activity”, Heterocycles 80 (1), 477-488, 2010
  20. K. Sadhu, M. Tamaki, T. Ohtsuki, K. Toume, T. Koyano, T. Kowithayakorn, M. Ishibashi, “Cadinane sesquiterpenes from Curcuma parviflora”, Journal of Natural Products 72 (4), 782-783, 2009
  21. Ito, S. Kamo, S. K. Sadhu, T. Ohtsuki, M. Ishibashi, Y. Kano, “Structure of new monoterpene glycoside from Sibiraea angustata RCHD. and its anti-obestic effect”, Chemical and Pharmaceutical Bulletin 57 (3), 294-297, 2009
  22. N. Jahan, M. S. Rahman, M. M. Rahman, S. Gibbons, M. M. Masud, S. K. Sadhu, M. Hossain, C. M. Hasan, M. A. RASHID, ”Diphenylpropanoids from Quisqualis indica Linn. and their anti-staphylococcal activity”, Latin American Journal of Pharmacy 28 (2), 279-283, 2009
  23. S. K. Sadhu, Khatun, T. Ohtsuki, M. Ishibashi, “Constituents from Hoya parasitica and their cell growth inhibitory activity”, Planta Medica 74, 760-763, 2008
  24. S. K. Sadhu, Khatun, T. Ohtsuki, M. Ishibashi, “First isolation of sesquiterpenes and flavonoids from Zingiber spectabile and identification of zerumbone as the major cell growth inhibitory component”, Natural Product Research 21 (14), 1242-1247, 2007
  25. S. K. Sadhu, Khatun, P. Phattanawasin, T. Ohtsuki, M. Ishibashi, “Lignan glycosides and flavonoids from Saraca asoca with antioxidant activity”, Journal of Natural Medicines 61 (4), 480-482, 2007
  26. S. K. Sadhu, M. S. Khan, T. Ohtsuki, M. Ishibashi, “Secoiridoid components from Jasminum grandiflorum”, Phytochemistry 68 (13), 1718-1721, 2007
  27. Tamaki, S. K. Sadhu, T. Ohtsuki, K. Toume, T. Koyano, T. Kowithayakorn, M. Ishibashi, “Parviflorene J, a cytotoxic sesquiterpene dimer with a new rearranged skeleton from Curcuma parviflora”, Heterocycles 72, 649-654, 2007
  28. Aoki, T. Ohtsuki, S. K. Sadhu, M. Sato, T. Koyano, S. Preeprame, T. Kowithayakorn, M. Ishibashi, “First isolation of three diterpenes as naturally-occurring compounds from Sindora siamensis”, Journal of Natural Medicines 61 (1), 77-79, 2007
  29. K. Sadhu, E. Okuyama, H. Fujimoto, M. Ishibashi, “Diterpenes from Leucas aspera inhibiting prostaglandin-induced contractions”, Journal of Natural Products 69 (7), 988-994, 2006
  30. K. Sadhu, E. Okuyama, H. Fujimoto, M. Ishibashi, E. Yesilada, “Prostaglandin inhibitory and antioxidant components of Cistus laurifolius, a Turkish medicinal plant”, Journal of Ethnopharmacology 108 (3), 371-378, 2006
  31. J. A. Shilpi, M.T. U. Rahman, S. J. Uddin, M. S. Alam, S. Sadhu, V. Seidel, “Preliminary pharmacological screening of Bixa orellana L. leaves”, Journal of Ethnopharmacology 108 (2), 264-271, 2006
  32. S. K. Sadhu, Hirata, X. Li, T. Koyano, S. Preeprame, T. Kowithayakorn, T. Ohtsuki, M. Ishibashi, “Flavonoids and sesquiterpenoids constituents from Eupatorium capillifolium found in a screening study guided by cell growth inhibitory activity” Journal of Natural Medicines 60 (4), 325-328, 2006
  33. K. Sadhu, F. Ahmed, T. Ohtsuki, M. Ishibashi, “Flavonoids from Sonneratia caseolaris”, Journal of Natural Medicines 60 (3), 264-265, 2006
  34. S. K. Sadhu, P. Phattanawasin, M. S. Choudhuri, T. Ohtsuki, M. Ishibashi, “A new lignan from Aphanamixis polystachya Journal of Natural Medicines 60 (3), 258-260, 2006
  35. K. Sadhu, E. Okuyama, H. Fujimoto, M. Ishibashi, “Separation of Leucas aspera, a medicinal plant of Bangladesh, guided by prostaglandin inhibitory and antioxidant Activities”, Chemical and Pharmaceutical Bulletin 51 (5), 595-598, 2003